Metrics details. Lower serum total TC, high-density lipoprotein HDL-C and low-density lipoprotein cholesterols LDL-C have been linked to an increased risk of cancer in various sites, but its underlying mechanism remains unclear. In an attempt to clarify the association between cholesterol levels and oxidative DNA damage, we investigated the relationship between serum cholesterol and urinary 8-hydroxydeoxyguanosine levels in a Japanese working population. Urinary 8-hydroxydeoxyguanosine 8-OHdG was measured using an automated high-pressure liquid chromatography. Subgroup analyses were conducted by smoking status in men and age in women. Lower circulating total TC [ 1 — 3 ], high-density lipoprotein HDL-C [ 4 ] and low-density lipoprotein cholesterols LDL-C [ 5 ] have been shown to be associated with an increase risk of total cancer, as well as cancer of the lung, prostate, stomach or colon [ 6, 7 ].
In recent years, there has been an unusual amount of conjecture as to the significance of the configurational similarity of the sex hormones, bile acids, vitamin D, cholesterol and the carcinogenic polycyclic hydrocarbons. Much speculation has been devoted particularly to the chemical relationship between the sex hormones and carcinogenic principles in the etiology of cancer. Sobotka 1 quoted Cook, who stated that “the cell proliferation which characterizes the estrous state is in some respects reminiscent of the early stages of malignant growth,” and Sobotka further conjectured that, while biodehydrogenation of sterols or bile acids may be the physiologic method for the production of the sex hormones, further dehydrogenation by a faulty mechanism may give rise to tumor-stimulating substances. Sobotka and Bloch 2 were unable to find any positive chemical or biologic evidence for the presence of carcinogenic hydrocarbons in large quantities of pooled urine from patients with cancer. However, they. Arch Intern Med Chic. Coronavirus Resource Center. This Issue. Save Preferences.
Median interquartile range 8-OHdG concentration checked before statistical analysis. Study participants were asked to fill out the survey questionnaire research staff for completeness. For continuous variables, normality was was 3.