High-protein diets may help people lose weight and build muscle, but there is a downside to it, a greater heart attack risk. Researchers now report that high-protein diets boost artery-clogging plaque. The research in mice showed that high-protein diets spur unstable plaque — the kind most prone to rupturing and causing blocked arteries. More plaque build-up in the arteries, particularly if it’s unstable, increases the risk of heart attack. Louis, Missouri. We decided to take a look at whether there is truly a causal link between high dietary protein and poorer cardiovascular health,” Razani added. The researchers studied mice who were fed a high-fat diet to deliberately induce atherosclerosis, or plaque build-up in the arteries. Some of the mice received a high-fat diet that was also high in protein.
Hypercholesterolemia increases endothelial superoxide anion production. Leeuwenburgh et al. But the environment inside plaque can overwhelm these cells, and when such cells die, they make the problem worse, contributing to plaque build-up and increasing plaque complexity. Identification of a denitrase would provide evidence that protein 3-nitrotyrosine is not formed randomly and has physiological significance in cellular signaling. Download citation. Biochemical FT-IR-based plaque imaging detected areas of low protein and high cholesterol ester content.
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