Experts aren’t exactly sure how clonazepam works, but believe its effects are due to its ability to strongly bind to the GABA-benzodiazepine receptor complex, which enhances the affinity for GABA a neurotransmitter that blocks impulses between nerve cells in the brain. Hindmarch I Psychomotor function and psychoactive drugs. Radmayr E Clobazam and Diazepam in der ambulanten psychiatrischen Behandlung neurotischer Patienten. If used as prescribed and for the short-term, they are generally safe and well tolerated. Pretorius Authors C. May not be suitable for some people including those with pre-existing respiratory disease such as COPD or sleep apnea, acute narrow-angle glaucoma, a history of drug or alcohol abuse, at high risk of falls, women who are pregnant or breastfeeding, or people with kidney or liver disease.
The effects of two benzodiazepine anti-convulsants clobazam 20 mg and clonazepam 2 mg in a variety of psychomotor performance tests were compared in a placebo controlled double-blind acute oral dose study in ten healthy volunteers. Assessments included critical flicker fusion CFF threshold, the Sternberg memory scanning and choice reaction time CRT, peak saccadic velocity PSV and visual analogue scales, all previously shown to be sensitive to the effects of benzodiazepines. Clonazepam significantly increased memory scanning time compared to clobazam. Clobazam was remarkably free of cognitive and psychomotor side-effects. This is a preview of subscription content, log in to check access. Rent this article via DeepDyve. Robertson MM Current status of the 1,4 and 1,5-benzodiazepines in the treatment of epilepsy: The place of clobazam.
Benzodiazepines are a family of psychoactive drugs known for their useful purpose in a variety of conditions including anxiety, insomnia, seizures, muscle spasms, and agitation. They are generally safe and effective for short-term use, but addicts abuse benzodiazepines in large doses which can cause euphoria for the user and physical dependence. The dependence on benzodiazepines leads to painful withdrawal symptoms, and our benzo detox in Long Island has seen first-hand the damage a benzo addiction can cause. It is dangerous to detox from benzos on your own and we highly advise against doing so. There are short-acting and long-acting benzos which are a factor in how long the withdrawal will last. Unfortunately, a benzo withdrawal will be felt for a few weeks, up to a month, if you abuse large doses of benzodiazepines.
Mylan Pharmaceuticals Inc. Show 4 more references 10 of Therapiewoche —