Hence, these 10 studies reflect a high level of sponsorship bias. The key criteria for inclusion was having a clear entry criteria of a definition of insomnia at baseline. Chen Ruwe Independent company analysed the results; study funded by pharmaceutical company. Cochrane Database Syst Rev. Epidemiology of insomnia: what we know and what we still need to learn.
Which antidepressant medications are most effective for treating insomnia in patients with depression? There is no single antidepressant or class of antidepressants that is most effective for the treatment of insomnia in patients with depression. The use of antidepressant medications can have a positive impact on sleep physiology, but does not seem to improve subjective ratings of sleep quality. Strength of Recommendation: B, based on one qualitative study and one meta-analysis. The relationship between depression, insomnia, and treatment is complex. A meta-analysis of sleep and psychiatric disorders found that patients with comorbid sleep disturbances and depression typically have increased sleep latency, increased rapid eye movement REM sleep, increased midcycle awakening, decreased slow wave sleep, and shortened REM latency. Adapted with permission from Wilson S, Argyropoulos S. Antidepressants and sleep: a qualitative review of the literature. Studies have consistently demonstrated differences between objective and subjective sleep measures in patients taking antidepressants.
The phrase what are the best antidepressants for sleep are mistaken
The aim of this review article was to summarize recent publications on effects of antidepressants on sleep and to show that these effects not only depend on the kind of antidepressant drugs but are also related to the dose, the time of drug administration, and the duration of the treatment. Complaints of disrupted sleep are very common in patients suffering from depression, and they are listed among diagnostic criteria for this disorder. Moreover, midnocturnal insomnia is the most frequent residual symptom of depression. Thus, all antidepressants should normalize sleep. However, at least in short-term treatment, many antidepressants with so-called activating effects e. For sleep-promoting action, the best effects can frequently be achieved with a very low dose, administered early enough before bedtime and importantly, always as a part of more complex interventions based on the cognitive-behavioral protocol to treat insomnia CBT-I. For successful treatment of depression, it is necessary to understand the effects of antidepressants on sleep.